KP.2, a new set of Covid-19 Variant

Context

Recently, a new Covid- 19 variant named “  KP.2” has been detected increasing in the United States. 

• Till  mid-March, the cases were just 1% but now it is more than one quarter. 

About KP.2

• KP.2 is part of the group of mutant known as  “FLiRT” group: 
  • This nickname has come from the initials of the mutations of these variants.
• Descendant of JN.1: KP.2 originated from the JN.1 variant.
• Mutations: The KP.2 (JN.1.11.1.2) variant carries two specific mutations in its spike protein: S:R346T and S:F456L.
  • There’s also an additional mutation in a non-S protein compared to JN.1.
• Reproductive number of KP.2: A study conducted by researchers from Japan found that KP.2’s reproduction number is higher than JN.1 in different countries.:
  • However, despite its higher reproductive number, the infectivity of KP.2 is significantly lower (10.5-fold) than that of JN.1, as reported by TOI.

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Challenges and Protection 

• New variant (KP.2) might evade current vaccines: This variant is different from the one the latest vaccine targets (XBB.1.5).
  • Early studies suggest it might be able to infect even vaccinated people.
• Certain groups at higher risk: People over 65, pregnant women, and those with weak immune systems are more likely to get severely ill from COVID, including KP.2.
  • Vaccination recommended for high-risk groups: These groups, especially those who haven’t gotten the latest vaccine yet, are advised to get vaccinated for some protection.
• Prevention of serious illness: Even though the current vaccine might not fully block KP.2 infection, it can still help prevent serious illness.