Lymphatic Filariasis

12 Feb 2025

Lymphatic Filariasis

India has launched a nationwide Mass Drug Administration (MDA) campaign targeting 111 endemic districts across 13 states.

  • The initiative aims to eliminate Lymphatic Filariasis (LF) by 2027 through preventive measures.

About Lymphatic Filariasis

Lymphatic Filariasis

  • Lymphatic Filariasis is commonly known as “Hathi Paon” or Elephantiasis.
  • It is classified as a Neglected Tropical Disease (NTD).
  • Causal Agent: Lymphatic Filariasis is caused by parasitic nematodes (roundworms) of the family Filariodidea.
  • There are three types of filarial worms responsible for the disease:
    • Wuchereria Bancrofti: Responsible for 90% of cases.
    • Brugia Malayi: Causes most of the remaining cases.
    • Brugia Timori : Also contributes to the disease.
  • The infection is typically acquired in childhood and causes hidden damage to the lymphatic system.
  • Transmission Cycle: Adult worms reside in the lymphatic vessels and produce microfilariae that circulate in the blood.
    • Mosquitoes become infected when they bite an infected host, allowing the larvae to develop and spread to humans through subsequent mosquito bites.
  • Impact of Lymphatic Filariasis: The disease leads to severe physical disabilities and long-term health consequences.
    • It causes lymphoedema (swelling of limbs) and hydrocele (scrotal swelling), significantly impacting the quality of life.

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Neglected Tropical Diseases (NTDs)

  • Definition: NTDs are a diverse group of conditions caused by viruses, bacteria, parasites, fungi, and toxins. They lead to severe health, social, and economic burdens, mainly affecting impoverished tropical communities.
  • Global Impact: Over 1 billion people are affected, with 1.6 billion requiring interventions for prevention and treatment.
  • Examples of NTDs:
    • Bacterial: Leprosy, Trachoma
    • nya, RaParasitic: Lymphatic Filariasis, Schistosomiasis
    • Viral: Chikungubies
    • Fungal: Mycetoma
    • Toxin-related: Snakebite Envenoming

India’s Status on Lymphatic Filariasis

  • About 31 million people are estimated to be harbouring microfilaria (mf) and over 23 million suffer from filaria disease manifestations. 
  • 90% of India’s LF burden is concentrated in eight states: State of Bihar has highest endemicity (over 17%) followed by Kerala (15.7%) and Uttar Pradesh (14.6%). 
    • Andhra Pradesh and Tamil Nadu have about 10% endemicity.
  • The Indian government aims to eliminate Lymphatic Filariasis by 2027 through a combination of:
    • Mass Drug Administration (MDA).
    • Morbidity management.
    • Vector control strategies.

About Mass Drug Administration Campaign

  • The MDA campaign involves the supervised administration of a combination of anti-filarial medicines to all eligible individuals in Lymphatic Filariasis (LF)-endemic areas.

National Center for Vector Borne Diseases Control

  • The National Center for Vector Borne Diseases Control is an umbrella program focused on preventing and controlling vector-borne diseases.
  • It works to combat various vector-borne infections, including:
    • Malaria
    • Japanese Encephalitis
    • Dengue
    • Chikungunya
    • Kala-azar
    • Lymphatic Filariasis
  • Vector-borne diseases are infections transmitted to humans and animals through bites from blood-feeding insects such as mosquitoes, ticks, and fleas.

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  • Medicines are provided regardless of whether individuals show symptoms, ensuring widespread preventive coverage.
  • The MDA campaign follows two drug regimens for treatment:
    • Double Drug Regimen (DA) : A combination of Diethylcarbamazine Citrate (DEC) and Albendazole.
    • Triple Drug Regimen (IDA): A combination of Ivermectin, Diethylcarbamazine Citrate (DEC), and Albendazole.
  • Implementing Agency: The National Center for Vector Borne Diseases Control (NCVBDC) is responsible for leading the implementation of the MDA campaign.
  • Ministry in Charge: The Ministry of Health & Family Welfare oversees and supports the execution of the campaign.
  • Objective of the MDA Campaign: The primary goal is to eliminate Lymphatic Filariasis (LF) from 111 endemic districts across 13 states.
  • The campaign aims to eliminate microscopic filarial parasites present in the bloodstream of infected individuals, thereby preventing further transmission.

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