Endometriosis: Difination, Causes, Symptoms & Treatment

17 Feb 2024

Context: 

Consulting firm McKinsey has recently published a report that sheds light on the women’s health gap issue. 

Key Findings of the McKinsey Report

  • Women’s Health Gap Impact: McKinsey’s report shows that neglecting women’s health leads to 75 million years lost annually due to illness or early death, which is equal to seven days per woman each year.
  • Economic Benefits of Closing the Gap: Addressing women’s health disparities could boost the global economy by $1 trillion yearly by 2040.
    • It shows a positive correlation between women’s health and economic prosperity.
  • EndometriosisWomen’s Health Challenges: Women bear a heavier burden of poor health and disability. Due to poor health, women have to spend an average of nine years in ill health. 
    • This dramatically affects their well-being, productivity, and earning potential. 

About Endometriosis

  • Endometriosis is a painful chronic disease. 
  • This disease occurs when tissue similar to the lining of the uterus grows outside the uterus, like fallopian tubes, ovaries, intestine and within your pelvic cavity. 
    • The endometrium is the inner lining of the uterus. 
      • This tissue is what women shed during a menstrual period.
  • Inflammation and scar tissue: Endometriosis  can cause inflammation and form scar tissue in the pelvic area. 
  • EndometriosisStarting of Endometriosis: It can begin when the first period starts and continue until they reach menopause.

Causes

The exact cause is not known, but endometriosis is thought to arise due to:

  • Retrograde Menstruation:

    • Flow of blow backwards: Menstrual blood containing endometrial cells flows backwards through the fallopian tubes into the pelvic cavity during periods.
    • Endometrial cells may implant and grow outside the uterus.
  • Cellular Metaplasia:

Endometriosis

    • Endometrial-like cells: Cells outside the uterus change into endometrial-like cells and proliferate.
      • This transformation leads to the growth of endometriosis in ectopic locations.
  • Stem Cells:

    • Stem cells are believed to initiate the development of endometriosis.
    • The disease spreads throughout the body via blood and lymphatic vessels.
  • Estrogen Dependence:

    • Estrogen levels influence endometriosis.
    • Impact of High estrogen: Higher estrogen levels can increase inflammation, growth, and pain.  

Treatment

  • Treatments for endometriosis depend on symptom severity. No treatment currently offers a cure for the disease. 
    • Scotland’s trials: Recent reports from Scotland’s trials have shown the possibility of women soon having access to the first effective drug for endometriosis.
Also Read: Casgevy Therapy – A Gene Therapy For Sickle Cell Disease

 

News Source: The Hindu

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