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New Class of Antibiotic Against a Drug-Resistant Bacterium

January 6, 2024

GS Paper III Science and Technology

Context: Researchers have identified a new class of antibiotics with the potential to tackle a drug-resistant bacterium, Acinetobacter baumannii.

Zosurabalpin: New Class of Antibiotic for Drug-Resistant Bacterium

  • Zosurabalpin was found to be effective against CRAB (carbapenem-resistant Acinetobacter baumannii)-induced pneumonia and sepsis in mouse models.
  • Trials: The antibiotic has been evaluated in two phase I clinical trials.

About Acinetobacter baumannii

  • It is a bacterial pathogen primarily associated with hospital-acquired infections.
  • It is commonly associated with aquatic environments and colonizes the skin as well as the respiratory and oropharynx secretions of infected individuals.

What is Antimicrobial Resistance (AMR)?

  • Antimicrobial Drug Resistance or Antimicrobial Resistance (AMR) occurs when bacteria, viruses, fungi and parasites no longer respond to antimicrobial medicines.
  • Impact: Infections become difficult or impossible to treat, increasing the risk of disease spread, severe illness, disability and death.
  • Reason: AMR is a natural process that happens over time through genetic changes in pathogens. 

To Read More: Antimicrobial Resistance (AMR)

News Source: The Hindu

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