Biolumpivaxin: Lumpy Skin Disease Vaccine

11 Feb 2025

Biolumpivaxin: Lumpy Skin Disease Vaccine

Bharat Biotech in collaboration with the Indian Council for Agricultural Research(ICAR) has developed the world’s first Biolumpivaxin vaccine for the Lumpy Skin Disease (LSD).

  • The vaccine is developed by Biovet which is a Bharat Biotech group firm. 
  • The vaccine has recently received approval from the Central Drug Standards Control Organization (CDSCO), marking a significant milestone in India’s veterinary healthcare sector.

Key Features of Biolumpivaxin

  • Global First: Biolumpivaxin is the world’s first DIVA (Differentiating Infected from Vaccinated Animals) marker vaccine for Lumpy Skin Disease.
  • DIVA Technology: Enables differentiation between naturally infected and vaccinated animals, aiding in disease surveillance and control programs.
  • High Safety and Efficacy: The vaccine has been rigorously tested for quality, safety, and effectiveness.
  • Single-Dose Regimen: Administered once a year to cattle and buffaloes above 3 months of age.
  • Vaccine Strain: Developed using the LSD virus/Ranchi/2019 strain from ICAR-NRCE, Hisar.

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Lumpy Skin Disease (LSD)

  • Lumpy Skin Disease (LSD) is a highly contagious viral disease affecting cattle and buffaloes.
  • It is caused by the Lumpy Skin Disease Virus (LSDV), a member of the Poxviridae family. 
  • The first reported outbreak of LSD occurred in Zambia in 1929.
  • The LSD spreads through blood-sucking vectors like ticks and mites like houseflies, mosquitoes, etc. It also spreads through contaminated water, fodder and feed.
  • The disease leads to severe economic losses in the dairy and livestock industry due to reduced milk production, infertility, and mortality.

Biolumpivaxin

Differentiating Infected from Vaccinated Animals

  • DIVA vaccines are specially designed vaccines that allow for the differentiation between naturally infected and vaccinated animals. 
  • They are widely used in livestock disease control programs to prevent disease outbreaks while enabling disease surveillance and eradication efforts.
Advantages of DIVA Vaccines Disadvantages of DIVA Vaccines
  • Identify infected animals: DIVA vaccines can help identify infected animals so that special restrictions can be relaxed for vaccinated animals. 
  • Monitor vaccine efficacy: DIVA vaccines can be used to monitor the transmission of wild-type viruses in vaccinated populations. 
  • Less effective: DIVA vaccines may not be as effective as conventional vaccines. 
  • Special diagnostic tests: Special diagnostic tests are required to identify infected animals. These tests may not be as sensitive as conventional tests. 
  • Development: Developing DIVA vaccines can be challenging. 

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