Longevity Science

Advances in biotechnology, geroscience, artificial intelligence, and preventive healthcare have revived global interest in human longevity.

What Is Longevity Science?

• Longevity science (or geroscience) studies the biological mechanisms of aging and explores ways to delay age-related decline.
• It is the interdisciplinary study of aging and intersects with wellness, biotechnology, public health and socio-economic policy.

Key Concepts in Longevity Science

Healthspan and Lifespan

• Lifespan refers to total years lived.
• Healthspan refers to years lived in good health, free from chronic disease and disability.
• The goal of modern longevity science is to increase healthspan, not just lifespan.

Biohacking

• Defined as deliberate modifications to diet, lifestyle or biology to enhance health and performance.
• Includes use of wearables, supplements, advanced diagnostics and therapies like cryotherapy or hyperbaric oxygen chambers.

Blue Zones

• Geographic regions with high concentrations of centenarians (100 years old) and low rates of chronic disease.
• Originally identified in Okinawa (Japan), Sardinia (Italy), Nicoya (Costa Rica), Ikaria (Greece) and Loma Linda (USA).
• Singapore is a new addition; Kerala is sometimes considered an Indian blue zone, though data limitations exist.

Global Longevity Trends and Innovations

• Wellness Industry Growth: Valued at $6.8 trillion globally in 2024, projected to reach $9.8 trillion by 2029.
• Technology Integration: Use of AI for diagnostics, brain-mapping wearables (e.g., Brain X360 helmet), breath-analysis metabolic tests.
• Longevity Tourism: Emerging trends like noctourism (sleep-focused travel) and luxury wellness programs.
• Pharmaceutical Advances: Repurposed drugs like GLP-1 agonists being explored for healthspan extension.

Longevity Science in India

• Demographic Shift: India will have the world’s largest elderly population by 2067.
• The Longevity India Initiative (IISc): Flagship BHARAT Study aims to create India-specific biomarkers and health algorithms, moving beyond Western-centric medical data.
• Economic Potential: Longevity economy in India is growing and preventive healthcare market is expanding.

Significant Challenges for India

• Healthcare Mindset: Predominantly curative rather than preventive; low willingness to invest in wellness before illness.
• Data Gaps: Lack of accurate age and health data, especially in rural areas, hinders identification of blue zones and targeted interventions.
• Access and Equity: High cost of personalized longevity consultations (₹10,000 – ₹1 lakh) and advanced therapies.
• Infrastructure Deficit: Inadequate public health systems and elderly care facilities.
• Early Onset of Diseases: Lifestyle-related chronic conditions appear earlier in Indians (30s–40s) compared to Western populations.

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Way Forward

• Socio-Economic Policy Redesign: Extend retirement age and promote lifelong learning.
• • Develop AgeTech solutions for independent living.
• Public Health Priority: Basic preventive care, vaccination, nutrition and geriatric services are foundational before high-tech biohacking.
• Cultural Shift: Move from ageist attitudes to valuing and integrating older adults (termed “Generation Experienced” or “Gen E”) into society.

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