H5N1 Genome

PWOnlyIAS

April 28, 2025

H5N1 Genome

National Institute of Virology (NIV), Pune shared H5N1 genome sequence data with GISAID (Global Initiative on Sharing All Influenza Data).

  • Genome data sharing enables global tracking and helps in the timely development of public health responses.

About H5N1

  • Type: Highly Pathogenic Avian Influenza (HPAI) virus.
  • Virus Family: Orthomyxoviridae.Subtype: Influenza A virus (H5 hemagglutinin + N1 neuraminidase proteins).

PWOnlyIAS Extra Edge:

What is a Genome?

The complete set of DNA (or RNA for some viruses) in an organism, including all of its genes.

History

  • First detected: 1996 in geese in China.
  • First human case: 1997, Hong Kong.

Transmission

  • Primary: From infected birds (wild or domestic poultry) to humans.
  • Human-to-human transmission: Extremely rare and inefficient.
  • Routes:
    • Direct contact with infected birds or surfaces contaminated by their droppings.
    • Rarely via contaminated air (aerosols).

Mortality

  • Human mortality rate: ~60% (depending on healthcare access and virus strain).
  • High mortality in confirmed human cases compared to seasonal flu.

Vaccines & Treatment

  • No widespread human vaccine available yet.
  • Antiviral drugs like oseltamivir (Tamiflu) can be effective if administered early.

Concerns

  • Potential for mutation to enable efficient human-to-human transmission.
  • Risk of pandemic if genetic changes occur.

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UDAAN PRELIMS WALLAH
Comprehensive coverage with a concise format
Integration of PYQ within the booklet
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Quick Revise Now !
UDAAN PRELIMS WALLAH
Comprehensive coverage with a concise format
Integration of PYQ within the booklet
Designed as per recent trends of Prelims questions
हिंदी में भी उपलब्ध

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